Calcium entry blocker flunarizine for treatment of sudden deafness.

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Pharmacological Profile of Flunarizine: a Calcium Channel Blocker

Flunarizine is a non selective calcium channel antagonist. It is highly lipophilic compound which distributes preferentially in adipose tissue and passes the blood brain barrier readily. Numerous preclinical and controlled clinical studies, including double blind clinical studies in which the drug was compared with placebo or standard drugs in particular disease showing efficacy in migraine, ve...

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Sudden deafness

The author explains the clinical presentation, pathophysiology, diagnostic work-up, and management of sudden deafness. "Sudden" deafness is defined as sensorineural hearing loss of 30 decibels or more in at least 3 contiguous frequencies occurring over less than 3 days. The pathophysiology of sudden deafness is poorly understood. Various theories have been proposed, including those attributing ...

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Effects of the topically applied calcium-channel blocker flunarizine on intraocular pressure in clinically normal dogs.

OBJECTIVE To determine effects of the topically applied calcium-channel blocker flunarizine on intraocular pressure (IOP) in clinically normal dogs. ANIMALS 20 dogs. PROCEDURES Baseline diurnal IOPs were determined by use of a rebound tonometer on 2 consecutive days. Subsequently, 1 randomly chosen eye of each dog was treated topically twice daily for 5 days with 0.5% flunarizine. During th...

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ژورنال

عنوان ژورنال: Practica Oto-Rhino-Laryngologica

سال: 1986

ISSN: 1884-4545,0032-6313

DOI: 10.5631/jibirin.79.2023